Replication-guided nucleosome packing and nucleosome breathing expedite the formation of dense arrays

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Replication-guided nucleosome packing and nucleosome breathing expedite the formation of dense arrays

The first level of genome packaging in eukaryotic cells involves the formation of dense nucleosome arrays, with DNA coverage near 90% in yeasts. How cells achieve such high coverage within a short time, e.g. after DNA replication, remains poorly understood. It is known that random sequential adsorption of impenetrable particles on a line reaches high density extremely slowly, due to a jamming p...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2014

ISSN: 1362-4962,0305-1048

DOI: 10.1093/nar/gku1190